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Data source, study protocol and patient selection Data for this investigation were accessed through the TriNetX Analytics platform, a global collaborative health research network widely used in numerous prominent epidemiological studies (Supplementary appendix) 43,44,45

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This disconnection between expectation and reality may have significant detrimental effects on self-esteem, confidence, and quality of life

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Fatigue during tirzepatide treatment may relate to caloric restriction from appetite suppression rather than a direct drug effect