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They sit near the top of the evidence hierarchy, just below meta-analyses (which combine multiple RCTs)

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

Eight-week treatment with 20 mg/day zinc also resulted in a significant decrease in BMI and BMI z score in obese children, although remaining abnormally high

Is Glutathione Therapy safe

doi: 10.1074/jbc.m207050200, 80

BPC 157 is considered to have a high safety profile with a lethal dose significantly higher than typical therapeutic doses, which range from 300 to 500 micrograms administered several times a week 5