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Possible mechanisms include central and autonomic nervous system dysfunction, as well as genetic and environmental factors

VEH treatments were anesthetised with isoflurane and decapitated (n = 58 animals/group)

doi: 10.1055/s-2007-1024895

Altogether, these findings suggest that certain -KG competitors including DM-succinate and ITA recapitulate -KG insufficiency to inhibit the YBX1AMPK axis in human cells, reinforcing the importance of -KG as an epigenetic cofactor for energy sensing

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Chemical functional groups on the surface of an INP, such as hydroxyl and amine groups, are hypothesized to initiate freezing by aligning water molecules in a similar structure to ice crystals 33