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OA affects 7% of the general population, and it is assessed that 1/3 of people over the age of sixty-five continue to be plagued by the complaint [4, 5]

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In healthy airways, FOXA2 negatively regulates goblet cell development, maintaining a balance between the need for mucus production and the prevention of excessive secretion (183, 184)

[85] reported that inhibiting Hedgehog signaling enhances O-GlcNAcylation of the transcription factors Foxp3 and STAT3, thereby driving Treg cells toward a Th17-like phenotype