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Proteomic analysis of liver proteins in a rat model of chronic restraint stress-induced depression

doi:10.1111/j.1749-6632.1980.tb21325.x

For this reason, it may be suggested that CV benefits evaluated in CV outcome trials should also reevaluate outcomes based on the magnitude of weight loss in post hoc analyses

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As semaglutide reduces weight, this risk should theoretically decrease, but the transition period, where rapid weight loss causes fluid shifts and muscle wasting, may temporarily increase risk before the long-term protective effects kick in