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GLP-1 drugs may be prescribed for the following conditions as per American Diabetes Association/European Association for the Study of Diabetes (ADA/EASD) 2025 guidelines 11 : Primary glycaemic indication: GLP-1 RAs are recommended for adults with type 2 diabetes who have not reached their individualised A1C targets (typically when A1C is 1.5% above the agreed glycaemic goal) despite lifestyle measures and foundational therapy such as metformin
Naslund E, Gryback P, Backman K, et al
[1] Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use semaglutide
When people eat 600-800 calories daily because their GLP-1 medication kills their appetite entirely, they lose weight fast initially but hit a devastating plateau within weeks, followed by worsening side effects and declining body composition
Haggag, A
GLP-1s cannot cross the skin unaided, Dr
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