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In the SURMOUNT-1 trial, tirzepatide produced average weight reductions of 15.0%, 19.5%, and 20.9% at studied doses compared with 3.1% with placebo over 72 weeks

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A standard compounded tirzepatide titration might look like: Month 1: 2.5 mg equivalent once daily Month 2: 5 mg equivalent once daily Month 3: 7.5 mg equivalent once daily Month 4+: 10 mg or higher as prescribed The tirzepatide dosing for weight loss follows established clinical trial protocols adapted for the sublingual route