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Akt activation leads to phosphorylation of key targets such as GSK3 , enhancing glycogen synthase activity, and FOXO1 , suppressing gluconeogenic enzymes[26-28,30]

By promoting the cell-mediated immune response and up-regulating IL-2 and interferon-gamma (IFN-), while down-regulating IL-1, IL-6, TNF- and granulocytemacrophage colony-stimulating factor (GM-CSF), sulforaphane suppresses the metastasis [39]