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Found in soy, flaxseed, and whole grains, phytoestrogens may either compete with endogenous estrogens for receptor binding, potentially exerting anti-estrogenic effects, or contribute to hormonal activity [88]

Early preclinical studies have also explored its potential to support overall gastrointestinal health, though human evidence remains limited

The development of the present therapeutic medicines in clinic mainly targets the discovered pharmacological targets, mainly focusing on the key receptors or enzymes

Whilst the concentration of melatonin used in vitro far exceeds that found in vivo , in vitro conditions lead to the rapid degradation of melatonin reducing its concentration swiftly over a 24h period

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Traditional medications such as Viagra and Cialis are known as PDE5 inhibitors