Immunotoxicity Testing: Methods and Protocols 1803:5779 Giletti A, Esperon P (2018) Genetic markers in methotrexate treatments
Lentz et al, 1996
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For example, SQRDL gene variant rs1044032 is associated with lower risk of PMOP (odds ratio 0.80), a finding validated in multiple East Asian populations
Although less exquisitely well-characterized mechanistically, retrograde NO is also involved in presynaptic plasticity in many brain regions, often serving to reduce excitatory Glu or increase inhibitory GABA release from afferent axons (Yang and Calakos, 2013)