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These diseases are characterized by painful blisters that form when the auto-Abs disrupt the integrity of the epithelial layers in the epidermis and/or mucosal membranes

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PFAS, especially PFOS, have been shown to activate the inflammasome, thus inducing IL-1 secretion and Caspase-1-mediated pyroptosis, thereby causing tissue inflammation [86]

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TABLE 1 Possible benefits and drawbacks of surgical and pharmacological interventions