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Despite the availability of multiple anti-seizure medications (ASMs) (French and Perucca, 2020), a significant portion of epilepsy patients continues to experience inadequate seizure control and adverse side effects such as depression, psychotic episode, irritability, and aggression (Hixson, 2014

Sati H, Carrara E, Savoldi A, et al

doi: 10.3109/14767058.2015.1079615

Metabolomics analysis showed a decrease in NADPH in hypoxic mutant chondrocytes, both during proliferation and differentiation, resulting in a reduced NADPH:NADP + ratio, indicating that hypoxic chondrocytes depend on the PPP for sufficient NADPH production and that other NADPH-generating pathways cannot compensate (Fig

These factors include VEGF, FGF, PDGF, IGF-1, HGF and EGF (215)

Teschke R, Uetrecht J (2021) Mechanism of idiosyncratic drug induced liver injury (DILI): Unresolved basic issues