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The strongest evidence involves small older insomnia studies showing modest short-term sleep effects, but no large modern randomized trials have confirmed reliable clinical benefits or established long-term safety

451 Of note, due to the lack of selectivity toward the suppression of mutant RAF dimers in cancer cells compared to the inhibition of wild-type RAF dimers in normal cells, LY3009120 showed limited efficacy at its maximum tolerated dose, 452 which prompts the generation of selective RAF dimer inhibitors to suppress resistant RAF dimers in tumors more effectively

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After an additional 36 h, 10 M MG132 was added for a further 12 h

Higher doses (12.515 mg/week) may be used in subsequent phases if tolerated and clinically indicated

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