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While these findings are observational and require confirmation in prospective studies, they highlight the potential of GLP-1 therapies to influence long-term musculoskeletal and inflammatory outcomes in patients with diabetes. For more information: Betul Ibis, MD, can be reached at [email protected].

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In the PV3-SC8 GPP3+GSH and PV3-SC8 pleconaril+GSH complexes, we observed that GSH binding resulted in some or all of these residues becoming ordered in the cryo-EM potential map, with Leu236 forming part of the binding site (Fig