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I follow quite closely the suggested treatment level for B12 deficiency with neurological damage because I dont think the treatment level specified for B12 deficiency with only blood symptoms, which is apparently what you are following, is adequate for achieving my two goals regarding neurological damage

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So, if you take medications to stop acid production such as a PPI ( omeprazole/pantoprazole and so on) it will reduce your absorption of Vitamin B12

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