Known and theoretical safety concerns include: Retatrutide (and the GLP-1 receptor agonist class): Nausea, vomiting, diarrhoea, and reduced appetite are the most commonly reported side effects
Endocrine Journal
Any references to biological activity are provided strictly for research context and must not be interpreted as claims of safety, efficacy, or intended human use
It is not medical advice and not a treatment recommendation
B12 is crucial in brain function, nerve tissue health, and red blood cell production
Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]