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Most people find them manageable, and they ease up after the first few weeks

Patients should also seek evaluation if they experience numbness, tingling, or color changes in fingers and toes (particularly white, blue, or red discoloration), which could indicate peripheral vascular issues or Raynaud's phenomenon rather than simple cold sensitivity

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If taken with insulin or an insulin secretagogue (ie sulfonylurea) it is best to talk to your healthcare provider about possibly lowering the dose of these medications to lower the risk of hypoglycemia

A 2.5 mg dose would be 100 units (1 ml) on a standard U-100 insulin syringe, assuming a concentration of 2.5 mg per ml

This timeline allows hormones to stabilize and skin sensitivity to return to baseline levels