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GLP-1 receptor agonists are typically recommended after trying metformin and other treatments, usually as a third-line option or in specific circumstances such as when weight loss would benefit other obesity-related comorbidities

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Prescribing information describes gastrointestinal adverse reactions as common, particularly during dose escalation, and clinicians typically individualize titration based on tolerability and patient history

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Willard FS, Douros JD, Gabe MB, Showalter AD, Wainscott DB, Suter TM, et al

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