Patients, athletes, healthcare workers and others use sterile solutions to help in medication delivery, injections, irrigation and other uses
Of these must-haves, only four are fat-soluble, meaning the body can store them within the fat cells when taken and/or consumed in excess
Work from David Savages group showed that PLIN1 mutations from patients with lipodystrophies, which lack the C-terminus, fail to stabilize ABHD5 on LDs, resulting in greater basal lipolysis (137) and likely explains why these patients are unable to sequester FAs into TAGs
The simplicity of the toolkit belies the importance of the technique
But understanding *why* requires a deeper look at both compounds
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