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Data are not reported here for subgroups with TZD owing to the low number of subjects receiving TZD in these trials: 5.4% and 2.3% of subjects receiving background TZD in SUSTAIN 2 and SUSTAIN 3, respectively [9, 10], and TZD was not included as a background therapy in SUSTAIN 4 or SUSTAIN 10 [11, 17]

It functions by activating GLP-1 receptors to regulate appetite and promote a feeling of fullness, which can contribute to reduced caloric intake

This does not eliminate muscle loss entirely, nothing can during significant caloric restriction, but it tilts the balance meaningfully

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Zhongguo Ying Yong Sheng li xueza zhi Chin J Appl Physiol 35:245249