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In SURMOUNT-1, participants on 15mg achieved an average weight loss of 22.5%, approximately 52 pounds or 24 kilograms over 72 weeks

Doubling daily KLOW intake (5 mg instead of 2.5 mg) produces stronger receptor downregulation without proportional metabolic benefit and may trigger transient side effects elevated heart rate, jitteriness, or sleep disruption if the double dose occurred in the evening

JAMA 333 , 8384 (2025)

[47] The ability of vitamin A to increase tumor response to radiation while reducing toxicity has been theorized to be due to the stimulation of immune response to tumor tissue