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For example, mitophagy mediated MQC heavily depends on efficient lysosome degradation, whose dysregulation reversely suppresses mitochondrial function, so they all interplay by each other to form a vicious cycle, participating in the pathogenesis of neurodegenerative diseases

Both types of cells communicate through secreted signaling factors

The main causes of B12 deficiency include inadequate dietary intake and malabsorption issues yet genetic predisposition to vitamin B12 deficiency has been demonstrated in various studies