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The DEG profile of the WCV group was more similar to that of the control group, whereas the DEG profile of the PD-1 group was different from that of both the control group and the VM group (Fig

When exposed to 100 dB SPL noise, both WT and Nrf2-KO mice exhibited increased gap detection ratios, indicating tinnitus-like behavior (Fig

In summary, SCLA1, SCLA2 and SCLA3 induced ferroptosis, which correlated with the identification of GPX4 as a target for these SCLAs in pulldown experiments and senescence selectivity of engagement with these SCLAs