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20 Three distinct groups of DPP4 inhibitors have been proposed based on the characterization of the binding mechanisms of the clinically most often used DPP4 inhibitors: Saxagliptin and vildagliptin, which belong to Class 1, engage with the S1- and S2 subsites of the active center and bind chemically to Ser630 of the DPP4 molecule

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Emerging principles of cytokine pharmacology and therapeutics

doi: 10.1177/2042098614551938

Oxyntomodulin exhibited even faster kinetics for G s conformational transitions and subunit dissociation than those induced by exendin-P5, and this was also correlated with more transient interactions at the base of the binding cavity and TM2

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