Faubion is just finishing up a study of 160 pre-, peri-, and postmenopausal women on GLP-1ssome of whom are also on MHTand hopes to have the results available by the fall
It enables long-chain fatty acids to be transported from the cytosol into the mitochondria (the power stations of the cells), where they can then be used to generate energy
Lancet Glob Health 12:e1534e1543
Importantly, life span extension of the glp-1(e2141) mutant was completely abolished when crossed with myt-1 mutants, suggesting a critical function of this gene in the longevity pathways activated by glp-1 deletion (Figure 8C and Supplemental Figure 6A)
But I guess my reaction is if you're a person who just needs to lose 10 pounds, I'm not convinced that the risk is worth it relative to the reward
GLP-1 Localisation and Proglucagon Gene Expression in Healthy and Diabetic Mouse Ileum