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Neuron-specific STING knockout significantly attenuated neuronal damage in EAE mice

reported that the combination of dexamethasone (DEX) and artesunate (ART) can be used to treat RA by regulating the HIF-1/NF-B signaling pathway, controlling ROS clearance, and reversing macrophage polarization (141)

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secondly, the study sample was relatively small

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When miR-146a levels rise, two key TLR signaling proteins, IRAK1 and TRAF6, may decrease, and thus they may not transmit inflammatory signals inside the cell, including pathways linked to NF-B activation, which would otherwise play a major role in inflammatory signaling