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This is the dose where dose-escalation-related side effects became clinically significant in the trial data

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[DOI] [PubMed] [Google Scholar] 101.Jacobs KM, Hirsch KA

In vivo data statistical analysis Statistical analyses for testing changes in the abundance of markers of peripheral inflammation or neuroinflammation were performed by constructing a linear model which was used as input for a least-squares means two-tailed t -test (described in detail below)