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The obesity drug Wegovy showed the strongest link to ischemic optic neuropathy, even though it had fewer overall reports than Ozempic, the diabetes formulation

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PLC-2 then competes with PI-3K for PIP 2 which it hydrolyzes into IP 3 (inositol 1,4,5-trisphosphate), which ultimately raises intercellular calcium, and diacylglycerol (DAG), which activates portions of the PKC family

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doi: 10.1080/10408398.2022.2164244 106 WangX.YuanW.YangC.WangZ.ZhangJ.XuD.et al