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Labeling evidence showing when the obstruction warning was added and whether physicians were informed in time

Large randomized trials of SGLT2 inhibitors report reductions in cardiovascular events (particularly hospitalization for heart failure) in patients with type 2 diabetes mellitus and in those with heart failure with reduced ejection fraction with or without diabetes

Expanding therapeutic indications beyond diabetes into obesity treatment multiplies the addressable market size

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Consequently, it may impact mood regulation indirectly [16]