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Rotating between sites each week prevents lipohypertrophy, a buildup of fatty tissue that can develop from repeated injections in the same spot

Yu ZF, Bruce-Keller AJ, Goodman Y, Mattson MP

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Naldemedine versus placebo for opioid-induced constipation (COMPOSE-1 and COMPOSE-2): two multicentre, phase 3, double-blind, randomised, parallel-group trials

doi: 10.1007/s00268-019-05218-1 58 LiuZWangRZhouJZhengYDongYLuoTet al