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SARS-CoV-2 mainly destroys pulmonary surfactant-secreting type II alveolar cells (Wang et al., 2021a), that normally decrease the air/tissue surface tension and block TLR4 in the lungs, promoting ARDS and inflammation

Patil A, Majumdar S

Epub 2011 Mar 1 Beyens A, Van Meensel K, Pottie L, De Rycke R, De Bruyne M, Baeke F, Hoebeke P, Plasschaert F, Loeys B, De Schepper S, Symoens S, Callewaert B