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Most patients notice reduced appetite and earlier satiety within the first few days to weeks of starting GLP-1 therapy, even at initial lower doses

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These can include: Allergic reactions, such as hives, swelling, or difficulty breathing Headaches or dizziness Nausea or gastrointestinal discomfort The Mayo Clinic advises that if you experience any of these symptoms, discontinue use and consult a healthcare professional immediately

Microdialysis or fastscan cyclic voltammetry studies have repeatedly reported that GLP1 receptor agonists acutely decrease accumbal dopamine efflux induced by substances of abuse

Thus, selection of indirect versus direct neurogenesis provides a powerful developmental and evolutionary instrument that drives not only the evolution of CNS complexity but also brain expansion and modulation of brain-region size, and thereby the evolution of increasingly advanced cognitive abilities