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Morali G, Montes P, Gonzalez-Burgos I, Velazquez-Zamora DA, Cervantes M

Improvements in symptoms related to vitamin deficiencies may start appearing within a few days or weeks after starting the injections

doi:10.1158/1078-0432.CCR-05-2290

In a 2-year rat carcinogenicity study, intranasal administration of dihydroergotamine mesylate (0, 0.4, 0.8 or 1.6 mg/day for 13 weeks, followed by 0, 0.08, 0.24 or 0.8 mg/day for the remainder of the study) did not result in an increase in tumors

Side effects can vary by dose, route, and patient sensitivity

These reactive oxygen species are produced by living cells as a metabolic byproduct and play a significant role as signaling molecules throughout the entire cell death process (2)