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The analysis of repeated treatment in the ShA study showed a significant effect of LIR treatment on active responding (F1,81 = 8.19, p = 0.005), indicating fewer active nose-pokes in LIR-treated rats

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The same annual HbA1c drift was assumed to continue, and once the HbA1c threshold of 9% (i.e., target 8.5% exceeded by 0.5%) was crossed, a switch to a basal + bolus insulin (+ metformin) regimen was modelled with an initial period 0.71% HbA1c change [39]