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RIPK3 subsequently phosphorylates MLKL, inducing its oligomerization and translocation to the cell membrane, where it forms ion channels or directly disrupts membrane integrity

39,40 Restoration of depleted GSH concentrations in T-cells may be critical for restoration of leukocyte function

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GSH is synthesized in a two-step reaction catalyzed by -glutamylcysteine synthetase and GSS in the -glutamyl cycle, which includes an additional four enzymes (Figure 1)