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However, there is sufficient evidence that glucagons lipolytic and thermogenic effects can be realized while successfully counteracting its hyperglycemic effect through careful integration of structurally related incretins

Abstract Aims/hypothesis Tirzepatide is a novel dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) currently under review for marketing approval

Circulation 141 , 6779 (2020)

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O.FeyderM.et al (2015)

"But we still need more evidence, including longer-term studies." GLP-1s don't work for everyone While GLP-1s may prove effective for some people, others may not respond at all