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FDA's concerns include potential immunogenicity for certain administration routes, peptide-related impurities, and the fact that Ipamorelin acetate contains unnatural amino acids that add characterization complexity

Summary Weight management dosing targets higher, sustained exposures than diabetes regimens, with typical semaglutide weekly doses ranging from 0.25 mg up to 2.4 mg and average weight loss around 15% over 18 months in reported programs

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Niu MY, et al

Semaglutide has longer real-world use data