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Furthermore, the GLP-1 secretion, which was inhibited by pasireotide in response to a high glucose level with L-glutamine and sodium butyrate stimulation, was significantly lower than the basal GLP-1 secretion in the low-glucose (0.1 mM) state in GLUTag cells (Fig

Specifically, radiation-induced lactate accumulation in cardiomyocytes triggers P4HB lactylation at lysine 311 (K311la), which subsequently initiates inflammatory cascades and mitochondrial autophagy

In contrast, the differential proteins between the AT group and the PT group exhibited different domain distributions, with a higher proportion of domains associated with oxidoreductase and chaperones ( Figure 3F )