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304 As mentioned above, the primary characteristics of IR are inhibited lipolysis in adipose tissue, impaired glucose uptake by muscle and inhibited gluconeogenesis in liver

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[DOI] [PubMed] [Google Scholar] 131.Jones K.L., Rigda R.S., Buttfield M.D.M., et al

It is an investigational compound presented here for research and educational purposes only and is not approved for general human use

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Renal Impairment JANUMET XR The dose of the sitagliptin component should be limited to 50 mg once daily if eGFR falls below 45 mL/min/1.73 m