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BPC 157 is far murkier: rodent studies suggest low acute toxicity, but we lack longterm human safety data, reproductive toxicity assessments, and robust immunogenicity workups

The pathogenesis of MTX-induced renal impairment is thought to be mediated by either MTX and its metabolites precipitating in the renal tubules or MTXs direct toxic impact on the renal tubules (Reference Widemann and Adamson6)

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Implementing such algorithms would be highly cost-effective [416]

A therapeutic dose is the amount of a medication required to achieve the desired clinical effect without causing significant side effects

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