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This has contributed to the interest in nontranscriptional effects of ER in the nervous system and may be a particularly useful strategy when dealing with cells that can project to sites at considerable distance

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These bioenergetic deficits contribute to muscle and neuronal fatigue ( This scoping review aims to examine the role of oxidative stress and mitochondrial dysfunction in FM, with a focus on redox imbalance, neuroinflammation, and potential therapeutic interventions targeting these pathways

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