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By contrast, the ER is expressed in the ovary, lung, prostate, colon, kidney, immune cells, and cardiovascular tissues

Since rapamycin treatment inhibits the alteration of PIP 3 and PTEN levels under insulin-resistant conditions, it is believed that the mTORC1 is involved in negatively regulating the IRS-1/PI3K/AKT signaling cascade downstream of the insulin receptor

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These medications likely activate these receptors and may affect the menstrual cycle in ways not yet understood. This represents an emerging area of research