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In addition to improving insulin resistance, a hypothesized mechanism in the progression of PD, in vitro and in vivo studies have shown that GLP-1 RAs can inhibit many pathways present in the pathogenesis of PD

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Current management strategies, including lifestyle modification, increased physical activity, and dietary intervention, have limited adherence and minimal prolonged success, wrote Mujdat Zeybel, of the NIHR Nottingham Biomedical Research Center, UK, and lead author of the new study

Toxicon 32 , 875882 (1994)

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