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Dosing usually begins low and increases slowly, with adjustments based on: Kidney health: Because Topamax leaves the body through the kidneys and can raise the chance of kidney stones, your provider may lower the dose or slow the titration if needed

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Your body settles into a rhythm with the medication

Another pathway is being targeted too Ziltivekimab from Novo Nordisk is being studied for its ability to reduce inflammation linked to cardiovascular risk, alongside blood pressure control