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GLP-1 receptor agonist molecules like semaglutide and tirzepatide are too large (4,100-4,800 daltons) to cross the skin barrier, which effectively blocks molecules above 500 daltons

Rani notes that its a good idea to avoid long or distant travel immediately after starting GLP-1 meds

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In clinical trials, gastrointestinal adverse events were reported by a significant proportion of patients, though most were mild to moderate in severity and transient in nature

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