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G6PD deficiency was first discovered by investigating a possible genetic basis for sensitivity to primaquine, and early studies have documented the clinical manifestation of primaquine-induced AHA in G6PD-deficient volunteers who were adults

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Histological analysis of adipose tissue from 5-Amino-1MQ-treated animals reveals increased presence of multilocular brown-like adipocytes, increased mitochondrial density, elevated expression of UCP1 and other thermogenic markers, and reduced adipocyte size

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