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10.3389/fendo.2022.1006376 37 DongY.WangP.YangX.ChenM.LiJ

Overview Glutathione (-L-glutamyl-L-cysteinyl-glycine) is a tripeptide synthesized intracellularly from glutamate, cysteine, and glycine by the sequential action of -glutamylcysteine synthetase and glutathione synthetase

In HD, there can also be disturbances in transcription and synaptic dysfunction [168], as well as deletions in mtDNA (mtDNA4977), particularly in mitochondria from the frontal and temporal lobes

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Yu C-J, Ko C-J, Hsieh C-H, Chien C-T, Huang L-H, Lee C-W, et al