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Arrowhead Pharmaceuticals, for example, is developing RNA-based therapies that silence specific genes expressed in the liver and adipocytes

PMID: 24868018

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Additionally, the RCTs primarily involved EX interventions, which may further reduce GOAT activity by redistributing blood flow from the splanchnic region to active muscles [171], although long-term effect remains unclear

It can also contribute to the prevention of fat deposition and delay the effect of fatigue during training

Treatment should not be delayed if neurological symptoms occur, as nerve damage may become irreversible without prompt B12 replacement