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After initial deacreases in GR activities in both roots and shoots up to 10 days a remarkable increase of enzyme activities was found after 15 days of treatment [21]

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The specific functional logic is as follows: In addition to GPR activation, SCFAs (especially butyrate) cross the blood-brain barrier via monocarboxylate transporter 1 (MCT1) and inhibit HDAC1/2 in the hippocampus and prefrontal cortexbrain regions critical for mood regulation

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