12 The Raf-MEK- ERK mitogen activates the protein kinase pathway, which is triggered by growth factors, hormones and cytokines that regulate the proliferation, differentiation, survival, senescence, and migration of tumor cells
Results High doses of GLP1-based multi-agonists improve metabolic function in murine models of PCOS We explored metabolic, hormonal, and gonadal responses to different GLP1-based multi-agonists in two experimental (mouse) models of PCOS, namely PWA (postweaning androgenization) and PNA (prenatal androgenization)
Two-way ANOVA with repeated measures revealed that no significant treatment (F 1, 9 = 0.112, p = NS), no time effect (F 3, 27 = 1.174, p = NS) and no treatment time effect (F 3, 27 = 1.926, p = NS)
Cells from each experimental group were added to the DCFH-DA solution and incubated in a 37 C cell incubator for 25 min, cells were collected by centrifugation
doi:10.1038/s41598-021-95481-x
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